POTENTIAL IMPACTS OF SAGE (SALVIA OFFICINALIS L.) LEAVES EXTRACT AND XANTHOPHYLLOMYCES DENDRORHOUS CULTURAL FILTRATE ON DIMETHYLFORMAMIDE INDUCED PHYSIOLOGICAL RESPONSES AND HEMATOTOXICITY IN MICE

The purpose of this study was to assess the potential effects of Salvia
officinalis ethanolic leaves extract (SEE) and Xanthophyllomyces
dendrorhous culture filtrate (XDCF) on physiological and hematological
responses in mice injected interperitoneally with dimethyl formamide
(DMF). Twelve groups comprised equally of 36 male and female Swiss
albino mice were divided into 6 groups of males and 6 groups of females
were represented (3 animals each). The experimental administrations were
the same for the male and female groups. The first group was the control
group. Every day for 21 days, the second, third, and fourth groups received
378 mg of DMF intraperitoneally, 100 mg of SEE orally, and 3300 µl of
XDCF intraperitoneally / kg body weight, respectively. The fifth group
received 100 mg of SEE / kg body weight orally every day for a further 21
days after receiving 378 mg of DMF / kg body weight intraperitoneally
every day for 21 days. Following a 21-day intraperitoneally exposure to 378
mg of DMF / kg body weight per day the sixth group was given daily XDCF
intraperitoneally by 3300 µl / kg body weight. In response to DMF
administration, the percentages of the liver, kidney, and heart significantly
increased while the percentages of the spleen and lung significantly
decreased in both males and females mice compared to the control group.
RBCs, Hb%, and PCV% were hematological indicators that significantlyreduced due to DMF administration. SEE and XDCF alleviated the adverse
effects of DMF on growth performance indicators, various organs, and
hematological parameters. These results demonstrate the potential of SEE
and XDCF as anti-toxin agents with a broad range of beneficial health
impacts.