BIOCHEMICAL IMPROVEMENT INDUCED BY SILYMARIN AND NANO SILYMARIN IN EHRLICH ASCITES CARCINOMA BEARING MICE

Silybum marianum (L.) was regarded as one of the wonder plants
through the last decades. The main bioactive compound in Silybum
marianum is silymarin. Therefore, the present study aimed to evaluate the
Silymarin and Nano silymarine activities on mice with induced Ehrlich
Ascites Carcinoma (EAC). Sixty Swiss albino female mice (weigh 20–22 g)
were randomly divided into equal four groups, 15 rats each. The first one
didn't receive any treatment and served as the standard control. Each of the
three remaining groups received 2.5 x 106 EAC cells intraperitoneally. The
second group didn't receive further treatment and served as the EAC control.
Silymarine and nano silymarine were administered orally at 100mg/kg b.w
dailly for 6 weeks to mice in the third and fourth groups, respectively.
Biochemical parameters, including liver and kidney functions as well as
lipid profile, were evaluated in all experimental groups. Results revealed
that, mice with induced EAC displayed adverse influence on the
biochemical parameters. The animals treated with silymarine and nano
silymarine extracts exhibited significant improvements in the biochemical
parameters following treatment, with a stronger impact in case of nano
silymarine.