ETHANOLIC SINAPIS ALBA LEAVES EXTRACT: A NOVEL APPROACH TO COUNTERACTING SODIUM NITRITE INDUCED INJURY IN EXPERIMENTAL RATS

RACT
In light of the increasing trend of using herbal remedies to treat a variety
of diseases. This study evaluates the antioxidant qualities present in the
ethanolic leaf extract of Sinapis alba (S. alba). As well as evaluating the
content of phenols and flavonoids, and their effectiveness in protecting the
heart from heart disease caused by sodium nitrite (SN) in rats (30 mg/kg body
weight). Four experimental groups (control, S. alba, SN, and S. alba + SN)
with six rats each were carefully examined over a period of six weeks. The
administration of SN significantly increased oxidative stress markers like
MDA and LDH and decreased antioxidant enzymes like CAT, GSH, and
SOD. It also significantly increased levels of AST, ALT, LDL, cholesterol,
triglycerides, and decreased HDL levels. Surprisingly, S. alba leaf extract
significantly improved these biochemical and cardiac tissue histological
changes induced by SN (P < 0.05). The study shows unequivocally that S.
alba ethanolic leaf extract has a strong cardioprotective effect against damage
caused by SN